We invented a composite cell culture substrate, with microdomains of defined rigidity, for probing the mechanism of rigidity sensing and efficient screening of sensing defects. |
Following up on the earlier discovery of durotaxis, we are applying composite substrates with defined rigidity patterns to probe the mechanism of rigidity sensing. |
We suggested that cells may detect their own shape and size based on the required mechanical forces to maintain the shape and the associated changes in focal adhesion size. |
We demonstrated that adherent cells prefer to stay in 2D areas rather than 1D lines, possibly due to the difference in traction forces.   |
We proposed a universal mechanical mechanism at focal adhesions capable of responding to a number of environmental and intracellular physical cues. |
To dissect regional function and coordination during cell migration, we combined micropatterning and microfluidics to apply inhibitors to specific regions of migrating cells to determine the responses. |
