Overview | Cell Structures | Cell Migration | Cell Division |
Substrate Dimensionality as a Guidance Cue for Cell Migration |
Chang et al, Biophys. J. 104:313-321 (2013) |
Since cell behavior is known to differ significantly in 1D, 2D, or 3D environments, we hypothesize that migrating cells are able to sense the dimension of the environment as a guidance cue.This possibility was investigated by culturing NIH 3T3 fibroblasts on micropatterned substrates where the path of migration alternates between 1D lines and 2D rectangles. |